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Structural studies on orbivirus particles

Reference	B07085
Principal Investigator / Supervisor	Professor David Stuart
Co-Investigators / Co-Supervisors	Dr Andrew Metaxas
Institution	University of Oxford
Department	Laboratory of Molecular Biophysics
Funding type	Research
Value (£)	276,226
Status	Completed
Type	Research Grant
Start date	25/10/1996
End date	25/10/1999
Duration	36 months

Abstract

Low resolution structures have been obtained of the core particles of bluetongue virus (BTV- 1) and BTV-10. We plan to collect (using synchrotron radiation) a set of X-ray data for BTV-1 to 3.5 Angstroms resolution and for BTV-10 to somewhat lower resolution. Comparison of these two serotypes and with the structure of selenomethionated cores of BTV- 1 will facilitate the alignment of the amino acid sequences with the X-ray structures and lead to refined atomic models. To date, no other structure of such complexity has been solved by X-ray crystallography; we hope to learn how these complex assemblies of molecules are formed and maintained, and to extend the study to core particles of other orbiviruses and to complete virus particles.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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