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Mechanisms of methane mono-oxygenase
Reference
B07030
Principal Investigator / Supervisor
Professor H Dalton
Co-Investigators /
Co-Supervisors
Professor John Murrell
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
158,724
Status
Completed
Type
Research Grant
Start date
09/05/1997
End date
09/05/2000
Duration
36 months
Abstract
We propose to carry out a detailed and systematic study of the molecular mechanisms of biological methane oxidation by methane mono-oxygenase. This will be achieved by combining expertise in the molecular biology and genetics of methane oxidising bacteria with studies on the biochemistry and biophysics of the enzyme. We will elucidate, by site-directed mutagenesis, the role of key amino acids in regulating the flow of electrons to the active site, the role of specific amino acids in the 'carboxylate shift' reaction and substrate binding.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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