Award details

Mechanism of viral polyprotein synthesis termination and cleavage/re-start in eukaryotic ribosomes

Reference	B06902
Principal Investigator / Supervisor	Professor David Gani
Co-Investigators / Co-Supervisors	Professor Martin Ryan
Institution	University of Birmingham
Department	School of Chemistry
Funding type	Research
Value (£)	282,723
Status	Completed
Type	Research Grant
Start date	01/01/1997
End date	01/03/2000
Duration	38 months

Abstract

Contrary to all expectations we have shown that aphthoviral 2A-mediated cleavage of polyproteins is not a proteolytic event, but occurs during synthesis in the ribosome. We describe a series of experiments specifically designed to test and refine our concept of this unique cleavage mechanism. To achieve our objectives we wish to exploit the extensive range of molecular biological and chemical tools that we have now designed and prepared in our laboratory to maintain our leading position and underpin the use of 2A in manifold biotech applications. This knowledge is of fundamental importance in disease processes, and our investigative techniques will be of generic application in delineating biomolecular function.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search