BBSRC Portfolio Analyser
Award details
A structural approach to the enzymology of biotin biosynthesis
Reference
B06790
Principal Investigator / Supervisor
Professor Lindsay Sawyer
Co-Investigators /
Co-Supervisors
Professor Robert Baxter
Institution
University of Edinburgh
Department
Inst of Cell and Molecular Biology
Funding type
Research
Value (£)
174,552
Status
Completed
Type
Research Grant
Start date
01/10/1996
End date
01/11/1999
Duration
37 months
Abstract
The aim is to complete our successful studies of the detailed molecular mechanism of the Escherichia coli bioD gene product, dethiobiotin synthetase, using substrate analogues and site-directed mutants to examine especially product release but now to include other members of the pathway which we have now over-expressed and purified. These are the gene products bioA diaminopelargonic acid aminotransferase, bioF ketoaminopelargonic acid synthetase and bioB, biotin synthase, which is now known to require a flavodoxin/ferredoxin reductase (the fpr gene product which we have crystallised) and probably one further protein component.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search