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Tumour necrosis factor receptor/nerve growth factor receptor superfamily: structure and function
Reference
B06675
Principal Investigator / Supervisor
Professor James Naismith
Co-Investigators /
Co-Supervisors
Institution
University of St Andrews
Department
Biology
Funding type
Research
Value (£)
102,568
Status
Completed
Type
Research Grant
Start date
01/12/1996
End date
01/12/1998
Duration
24 months
Abstract
Type I tumour necrosis factor receptor (TNF-R1) is currently an important topic in medical and scientific research. The interest focuses on how the receptor actually signals and how this signalling may be controlled to therapeutic advantage. A similar strategy is being pursued for a class of structurally related receptors, such as FAS and nerve growth factor. This family control some of the most important processes in human physiology including cell death and neural programming. We will solve 2 high resolution structures of the extracellular domain of the TNF-R1. With this information, we will generate the first molecular models of structurally related receptors. This project will make important contributions to our understanding of receptor signalling.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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