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Efficiency of enzyme catalysis: new glycosidase and phosphodiesterase models with two catalytic groups
Reference
B06647
Principal Investigator / Supervisor
Professor Anthony Kirby
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
162,127
Status
Completed
Type
Research Grant
Start date
01/10/1996
End date
31/01/2000
Duration
38 months
Abstract
The long term objective of this work is a detailed understanding of the chemistry of enzyme catalysis. Within the timescale of this grant we aim to test our most recent ideas on the ways enzymes catalyse particularly slow reactions of fundamental importance. The tests involve the design and synthesis of model systems for glycosyl and phosphoryl transfer from phosphodiesters with two (or more) catalytic groups, each operating with optimal efficiency, and a search for synergy between the coupled bond-making and bond-breaking processes involved. The results will bear directly on the limits of efficiency feasible in artificial enzyme systems.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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