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Characterisation of catalytic IgG from polyclonal preparations: isolation and kinetics and protein chemical studies

Reference	B06639
Principal Investigator / Supervisor	Professor K Brocklehurst
Co-Investigators / Co-Supervisors
Institution	Queen Mary University of London
Department	Sch of Biological and Chemical Sciences
Funding type	Research
Value (£)	132,504
Status	Completed
Type	Research Grant
Start date	01/04/1997
End date	01/04/2000
Duration	36 months

Abstract

(i) To optimise the separation of catalytic from non-catalytic IgG in polyclonal preparations achieved in preliminary work (Seedcorn grant and subsequently); (ii) To evaluate kinetically and by chemical modification fractionated and non-fractionated catalytic IgG to test the hypothesis arising from our published work that polyclonal IgG may be a particularly valuable source of highly effective novel catalysts which may be functionally homogeneous, and (iii) To contribute to our understanding of the types of chemical catalysis that are recruited by catalytic antibodies and their modulation by variation in immunogen structure.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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