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pH-responsive pseudoproteins for selective extracellular targeting

Reference	B06490
Principal Investigator / Supervisor	Professor Nigel Slater
Co-Investigators / Co-Supervisors	Professor Brian Tighe
Institution	Aston University
Department	Sch of Engineering and Applied Science
Funding type	Research
Value (£)	112,277
Status	Completed
Type	Research Grant
Start date	01/07/1996
End date	01/07/1998
Duration	24 months

Abstract

To devise a range of novel, pH-responsive pseudoproteins whose structure can be varied to allow in vivo precipitation over a defined pH range typical of that encountered within solid tumours and which are degradable to non-toxic metabolites. The specific objectives of this investigation are to: 1) design and synthesise polymers that can be used to probe the pH microenvironment within solid tumours through site specific chemical change. 2) Characterise the pH response of the polymers in aqueous solution through studies of surface activity and solubility. 3) Demonstrate the in vitro potential of the polymers to act as tumour embolising agents.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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