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Combinatorial exploration of protein-small molecule interactions
Reference
B06157
Principal Investigator / Supervisor
Professor Laurence Pearl
Co-Investigators /
Co-Supervisors
Dr Robert Drew
Institution
University College London
Department
Structural Molecular Biology
Funding type
Research
Value (£)
161,560
Status
Completed
Type
Research Grant
Start date
01/10/1996
End date
01/10/1999
Duration
36 months
Abstract
We propose to use our knowledge of the structure and biology of AmiC, a small-molecule binding protein which regulates the amidase operon of Pseudomonas aeruginosa, to produce a selectable combinatorial library of small-molecule binding specificities. We will use this library to select variants which recognise target ligands, particularly those containing chemical groups which are important pharmacophores, but which do not occur in biological macromolecules. Selected AmiC variants will be sequenced and expressed, and the structure of the protein-ligand complex determined by X-ray diffraction.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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