BBSRC Portfolio Analyser
Award details
Dimerisation of G-protein coupled receptors
Reference
B06081
Principal Investigator / Supervisor
Professor Christopher Reynolds
Co-Investigators /
Co-Supervisors
Institution
University of Essex
Department
Biological Sciences
Funding type
Research
Value (£)
34,012
Status
Completed
Type
Research Grant
Start date
06/05/1996
End date
06/05/1998
Duration
24 months
Abstract
Observation by Maggio offer evidence of G-protein coupled receptor dimerisation, indicating that these receptors possess flexible structures. The Maggio rearrangement involves a one-seven dimer which rearranges via an open form to reform a five-six dimer. The range of possible dimer structures will therefore be investigated using molecular dynamics. Since the receptor canopy fits tightly, it is proposed that the ligand binds during the Maggio rearrangement. Consequently, a variety of techniques will be used to study the agonist-receptor encounter, including Brownian dynamics. It is hoped that this work will contribute towards a molecular understanding of high and low affinity forms and the receptor. This research will have implications for the structural determination of G-protein coupled receptors.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search