BBSRC Portfolio Analyser
Award details
Dissecting the stability of a small protein using peptide models
Reference
B05892
Principal Investigator / Supervisor
Professor Mark Searle
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
Sch of Chemistry
Funding type
Research
Value (£)
137,064
Status
Completed
Type
Research Grant
Start date
01/10/1996
End date
05/07/2000
Duration
45 months
Abstract
Understanding the relationship between the folded structure of a protein and its amino acid sequence remains one of the great challenges of contemporary science. Using spectroscopic techniques, particularly NMR and CD, the poorly-understood propensities of polypeptides to form beta-structures, and their role in initiating protein folding, will be studied using peptide models of the small, highly stable B1 domain of protein L (LB1). The stability of isolated N- and C-terminal beta-hairpins and analogues, and the mutual interaction between a subset of elements of secondary structure found in the native protein will be examined for partial self-assembly, and their ability to template the folding of LB1 as complementary peptide fragments.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search