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Single molecule fluorescence microscopic studies of DNA polymerase
Reference
B05823
Principal Investigator / Supervisor
Professor David Klenerman
Co-Investigators /
Co-Supervisors
Professor Sir Shankar Balasubramanian
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
132,048
Status
Completed
Type
Research Grant
Start date
01/06/1996
End date
01/06/1998
Duration
24 months
Abstract
We seek funds to perform proof of concept of experiments to demonstrate the application of single molecule fluorescence far field microscopy to study biological processes in real time. In particular by labelling DNA polymerase with fluorophores conformational changes on the binding of DNA will be studied. Fluorescence resonance energy transfer between a donor and acceptor on the DNA and DNA polymerase respectively will be used to follow DNA translocation in real time.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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