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Interactions of biological molecules studied using the atomic force microscope

Reference	B05796
Principal Investigator / Supervisor	Dr Robert Henderson
Co-Investigators / Co-Supervisors	Professor John Edwardson
Institution	University of Cambridge
Department	Pharmacology
Funding type	Research
Value (£)	243,564
Status	Completed
Type	Research Grant
Start date	01/01/1997
End date	01/01/2000
Duration	36 months

Abstract

The atomic force microscope will be used to study interactions between membrane proteins and other biological molecules. The project is divided into two parts, each part involving a system of potential therapeutic importance: (a) Investigation of the structure of an inwardly-rectifying ATP-sensitive K+ channel (ROMK1) and its modification by ATP binding, ATP hydrolysis or phosphorylation; (b) Investigation of the structural dynamics of a protein that controls intracellular membrane fusion. Both aspects of the study will be performed initially with cloned purified proteins attached to a mica substrate in physiological solutions, but subsequently they will be investigated and reconstituted in a lipid environment to more reflect the situation in the native environment.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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