BBSRC Portfolio Analyser
Award details
Studies on guanosine triphosphate cyclohydrolase I and dihydroneopterin aldolase
Reference
B05795
Principal Investigator / Supervisor
Professor D Young
Co-Investigators /
Co-Supervisors
Institution
University of Sussex
Department
Chemistry
Funding type
Research
Value (£)
141,492
Status
Completed
Type
Research Grant
Start date
01/06/1996
End date
02/12/1999
Duration
42 months
Abstract
The enzymes guanosine triphosphate cyclohydrolase I and dihydroneopterin aldolase are involved in the biosynthesis of the coenzyme tetrahydrofolic acid, and GTP cyclohydrolase I is also involved in the biosynthesis of the coenzyme tetrahydrobiopterin. This makes both enzymes key targets for therapeutic intervention. We intend to study the putative Amadori rearrangement mechanism for GTP cyclohydrolase I and the stereochemical outcome of both enzymic reactions. The work will also set up useful synthetic protocols for study of dihydropteroate synthase, a target for anti-bacterial drugs. New syntheses of the reduced pterin coenzymes will be developed in the course of the work.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search