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Structure of branchpoints in RNA molecules
Reference
B05705
Principal Investigator / Supervisor
Professor David Lilley
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
159,809
Status
Completed
Type
Research Grant
Start date
01/04/1996
End date
01/04/1999
Duration
36 months
Abstract
Helical junctions are very significant elements in biologically important RNA molecules, including snRNAs and some ribozymes. We have a great deal of experience in the study of the global structure of helical junctions in DNA, and we will use our methods to study three- and four-way junctions in RNA. This will involve principally electrophoretic methods, fluorescence resonance energy transfer and chemical probing. We aim to deduce the general folding principles for helical junctions in RNA, and apply this to a number of biological junctions including those in U1 snRNA, the U4/U6 complex of snRNA and the hairpin ribozyme.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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