Award details

Structural analyses of bluetongue virus (BTV) and its proteins

Reference	B05160
Principal Investigator / Supervisor	Professor Polly Roy
Co-Investigators / Co-Supervisors	Professor David Stuart
Institution	University of Oxford
Department	Laboratory of Molecular Biophysics
Funding type	Research
Value (£)	124,659
Status	Completed
Type	Research Grant
Start date	01/09/1995
End date	01/09/1998
Duration	36 months

Abstract

The primary objective of the proposed work is to determine the bluetongue virus (BTV) structure of VP7 and VP3 interactions by analysis of BTV core-like particles (CLPs) as surrogate of viral core particles. The CLPs can be synthesised in large quantities by expressing VP7 and VP3 using baculovirus expression vectors will be crystallised and analysed by X-ray diffraction on the available 3-dimensional structure of BTV VP7. The structure of VP7 and CLPs under alternative conditions (various pH etc.) and by cryo-electron microscopy as well as FAB-CLP complexes will also be analysed. In addition, the structural analysis of two minor proteins (VP6 and VP4) of the core will also be initiated.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search