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High resolution X-ray analysis of di-Mn catalase

Reference	B05117
Principal Investigator / Supervisor	Professor Peter Artymiuk
Co-Investigators / Co-Supervisors	Professor Pauline Harrison
Institution	University of Sheffield
Department	Krebs Institute for Biomolecular Researc
Funding type	Research
Value (£)	131,424
Status	Completed
Type	Research Grant
Start date	01/09/1995
End date	01/09/1998
Duration	36 months

Abstract

i) To determine the three-dimensional structure of di-manganese catalase at high resolution and thus to provide a basis for the interpretation of current spectroscopic data and to stimulate new, functional studies; ii) to compare the structures of di-Mn catalase and other proteins with dinuclear metal sites (eg ferritins, ribonucleotide reductase, di-Mn arginase) with the aim of elucidating structure-function relationships; iii) to crystallise recombinant human iron regulatory protein and E. coli aconitase for X-ray analysis.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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