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Structural studies on ADP-ribosylation factor (ARF) and members of the RHO family of small GTP-binding proteins
Reference
B05018
Principal Investigator / Supervisor
Dr Benjamin Bax
Co-Investigators /
Co-Supervisors
Professor Shamshad Cockcroft
,
Professor Alan Hall
Institution
Birkbeck College
Department
Biological Sciences
Funding type
Research
Value (£)
134,867
Status
Completed
Type
Research Grant
Start date
01/10/1995
End date
01/10/1998
Duration
36 months
Abstract
We have solved the crystal structure of the Ras related small GTP-binding protein ARF-1 complexed with GDP. ARF is involved in regulating intra cellular vesicle transport and phospholipase D activity. Funding is sought to pursue structural studies on ARF-1, in particular for the determination of crystal structures of mutant ARFs and ARF complexed to analogues of GTP. We also wish to initiate crystallographic studies on the Rho family of GTP-binding proteins, and an effector of Rac and Cdc42, the serine threonine kinase p65.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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