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Directed combinatorial chemistry - the utility of inverted libraries
Reference
B04846
Principal Investigator / Supervisor
Professor Mark Bradley
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Sch of Chemistry
Funding type
Research
Value (£)
212,031
Status
Completed
Type
Research Grant
Start date
01/11/1995
End date
31/10/1999
Duration
48 months
Abstract
The research proposal describes a new synthetic method that allows the synthesis and inversion of fully protected combinatorial libraries followed by their C-terminal modification. We propose to utilise these inverted and modified libraries in a variety of novel applications. This includes the preparation of the first combinatorial library to contain an active site directed inhibitor, a unique and exceptionally attractive antibacterial delivery system and a quenched fluorescent assay system to determine the specificity of new proteases. The inverted library will also be used to screen synthetic receptors that were designed to bind carboxylates.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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