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Structure determinations of a transmembrane peptide in bilayers by solid-state nuclear magnetic resonance (NMR) spectroscopy
Reference
B04750
Principal Investigator / Supervisor
Professor Anthony Watts
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Biochemistry
Funding type
Research
Value (£)
139,693
Status
Completed
Type
Research Grant
Start date
01/02/1996
End date
01/02/1999
Duration
36 months
Abstract
This project aims to determine the structures of a transmembrane in lipid bilayers using a non-crystallographic and non-perturbing method, namely novel solid state NMR. The peptide chosen can adopt an alpha-oligomeric or beta-oligomeric form, as resolved by CD, FTIR and Raman spectroscopy, depending upon conditions used for incorporation into bilayers. Intra- atomic distances between selected pairs of labelled (13C) carbon atoms in a bilayer-embedded peptide will be measured to resolve secondary structure dimensions and test indirect structural prediction methods. Intermolecular distances will permit helix-helix distances and associations to be assessed.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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