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Award details
Structure, function and chemistry of stress protein Lysu and mutants
Reference
B04481
Principal Investigator / Supervisor
Professor Andrew Miller
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Chemistry
Funding type
Research
Value (£)
135,705
Status
Completed
Type
Research Grant
Start date
01/11/1995
End date
01/11/1998
Duration
36 months
Abstract
LysU is a heat shock protein which efficiently catalyses the formation of diadenosine 5',5'''- p1,p4-tetraphosphate (Ap4A). Ap4A is apparently involved in the control of cell proliferation and management of the stress response (in both prokaryotic and eukaryotic cells) therefore Ap4A analogues are potentially potent therapeutic compounds. We have previously shown that LysU may synthesize a range of Ap4A analogues which are of interest to the pharmaceutical industry. As a result we propose to make use of our recently solved X-ray crystal structure of LysU to engineer rational mutants of LysU for preparative synthesis of further novel Ap4A analogues which will be evaluated as therapeutic agents by our industrial contacts.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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