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Time-resolved spectroscopy of free radical intermediates in protein-radical enzymes
Reference
B04230
Principal Investigator / Supervisor
Professor Roger Hugh Bisby
Co-Investigators /
Co-Supervisors
Institution
University of Salford
Department
Res Inst for the Built and Human Env
Funding type
Research
Value (£)
6,000
Status
Completed
Type
Research Grant
Start date
01/10/1994
End date
01/10/1997
Duration
36 months
Abstract
1. To use time-resolved resonance Raman spectroscopy to investigate the structure and interactions of free radical intermediates formed within the catalytic cycle of the TOPAquinone-containing enzyme copper amine oxidase. 2. To develop caged amine substrates which will allow objective 1) to be achieved using a two laser pump-probe method. 3. To use reaction techniques to measure the redox properties of the TOPAsemiquinone radical and related semi-iminoquinone radicals both in model systems and in copper amine oxidases. 4. To assess the feasibility of using similar techniques to study other protein- radical enzymes.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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