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Protein engineering and NMR spectroscopy of domains in multienzyme complexes
Reference
B04226
Principal Investigator / Supervisor
Professor Richard Perham
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Biochemistry
Funding type
Research
Value (£)
177,209
Status
Completed
Type
Research Grant
Start date
01/05/1994
End date
01/04/1998
Duration
47 months
Abstract
1. To determine the structures of the lipoyl domains of the 2-oxoglutarate dehydrogenase complex and the biotinyl domain of acetylCoA carboxylase. 2. To analyse domain interactions on the pyruvate dehydrogenase complex. 3. To map the structural determinants of post- translational modification and the specificity of the subsequent reductive acylation step in 2- oxo acid dehydrogenase complexes.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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