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A multiparameter study of peptide conformation
Reference
B04221
Principal Investigator / Supervisor
Professor Michael Williamson
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
97,497
Status
Completed
Type
Research Grant
Start date
01/10/1994
End date
01/10/1997
Duration
36 months
Abstract
To develop a protocol for including NOES, coupling constants, hydrogen bonding and chemical shifts into a simulated annealing calculation, using time averaging of constraints, and calculate dynamic structures for a range of peptides. Necessary prior steps include the assessment of heteronuclear shifts and amide exchange/temperature variation as structural parameters, and the measurement of heteronuclear coupling constants and relaxation at natural abundance.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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