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Host ligands and parasite molecules involved in recognition and entry of Cryptosporidium sporozoites into enterocytes
Reference
B03883
Principal Investigator / Supervisor
Professor Andrea Crisanti
Co-Investigators /
Co-Supervisors
Dr Kathryn Robson
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
269,143
Status
Completed
Type
Research Grant
Start date
01/06/1995
End date
28/02/1999
Duration
45 months
Abstract
TRAP (thrombospondin related anonymous protein) and the circumsporozoite (CS) protein of Plasmodium falciparum contain the thrombospondin adhesive motif WSPCSVTCG and play a role in the recognition and entry of P. falciparum into hepatocytes. Recently we have identified a Cryptosporidium gene and a partial DNA sequence coding for two distinct polypeptides each containing the motif WSPCSVTCG (TRAP-C1 and TRAP-C2). These proteins may represent in Cryptosporidium the functional homologues of TRAP and the CS protein. The aim of this proposal is to expand the basic knowledge of Cryptosporidium host- cell molecular interactions with special regard to the function of TRAP-C1 and TRAP-C2 and to the identification of their ligand on host cells.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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