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The structural relationship of fibrillin microfibrils and basement membranes
Reference
B03823
Principal Investigator / Supervisor
Professor Cay Kielty
Co-Investigators /
Co-Supervisors
Dr Charles Shuttleworth
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
170,618
Status
Completed
Type
Research Grant
Start date
01/09/1995
End date
31/01/1999
Duration
41 months
Abstract
The association of fibrillin microfibrils with basement membranes is a frequently recurring theme of fundamental significance in establishment and maintenance of connective integrity and function. Intercalation of microfibrils within basement membranes appears to underpin continuity of basement membranes and stromal matrix and to support major structural and mechanical microfibrillar roles. We propose to identify and characterise the molecular interactions that sustain this association and the developmental time-frame of formation of this crucial connective tissue interface, using cell and organ culture model systems and developing dermal and ocular tissues.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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