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Award details
The improvement of phases of macromolecular crystals
Reference
B03785
Principal Investigator / Supervisor
Professor Keith Wilson
Co-Investigators /
Co-Supervisors
Professor George Dodson
,
Dr Peter Main
Institution
University of York
Department
Chemistry
Funding type
Research
Value (£)
103,294
Status
Completed
Type
Research Grant
Start date
01/06/1995
End date
01/12/1998
Duration
42 months
Abstract
The proposal is for research into methods for improving electron density maps of macromolecular crystals based on density modification, symmetry averaging and other constraints on the phases. This project is aimed specifically at improving the SQUASH program, which has been developed in York and which applied a combination of phase constraints simultaneously. New features include the use of critical points in the electron density map to obtain molecular skeletons; use of the skeleton in density modification and in rapid translation and rotation searches and the use of improved figures of merit in an iterative procedure to increase the entropy of the map.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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