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Award details
The synthesis and biological properties of novel 4'-thio-2'-deoxynucleotides analogues and their oligodeoxynucleotides
Reference
B03752
Principal Investigator / Supervisor
Professor G Boons
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
School of Chemistry
Funding type
Research
Value (£)
109,047
Status
Completed
Type
Research Grant
Start date
01/10/1995
End date
01/01/1999
Duration
39 months
Abstract
We have shown that 4`-thio-2`-deoxynucleosides can now be readily prepared and that members of this novel class of compounds have interesting chemical and biological properties. This proposal intends to exploit these compounds in three ways: (1) An indepth investigation of the condensation reaction by which they are formed, in an attempt to reverse the current unfavourable alpha/beta ratio of products formed. (2) Study the chemistry of formation of and properties of sulfoxides and sulfones derived from these nucleosides. (3) To use polymers made from 4`-thio- 2`deoxynucleosides and their analogues to investigate a variety of problems in molecular biology involving nucleic acid-protein and nucleic acid-nucleic acid interactions.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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