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Suppression of IgE-mediated hypersensitivity to a major dust mite allergen by a chimaeric mouse-human IgG4 anti-idiotype

Reference	B03598
Principal Investigator / Supervisor	Professor Farouk Shakib
Co-Investigators / Co-Supervisors	Dr Michael Clark, Professor Herbert Fitzgerald Sewell
Institution	University of Nottingham
Department	Div of Molecular and Clinical Immunology
Funding type	Research
Value (£)	142,533
Status	Completed
Type	Research Grant
Start date	01/03/1995
End date	01/05/1997
Duration	26 months

Abstract

The production of antigen-specific IgE by B lymphocytes and the interaction of IgE with its high affinity receptor (FcepsilonRI) and subsequently with antigen (allergen) on mast cells, basophils and eosinophils are key events in the development of Type I hypersensitivity. The fact the IgE plays a central role in this sequence of events makes it a prime target for immunological strategies aimed at preventing allergic reactions. In this application, we propose to construct a chimeric mouse-human IgG4 anti-idiotype to investigate its ability to block the binding of allergen (Der p I of house dust mite) to allergen-specific IgE on basophils and to suppress the synthesis of allergen-specific IgE by B lymphocytes.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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