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Award details
Structure, function and protein engineering of aldolases
Reference
B03080
Principal Investigator / Supervisor
Professor William Hunter
Co-Investigators /
Co-Supervisors
Professor Alan Berry
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
105,936
Status
Completed
Type
Research Grant
Start date
04/04/1993
End date
31/07/1998
Duration
63 months
Abstract
We aim to determine the three-dimensional structure of a Class II fructose-1,6-bisphosphate aldolase using crystallographic methods and to characterise fully the structure-activity relationships of this enzyme. To then utilise protein engineering methodology to redesign the enzyme's active site so creating new aldolases with designed specificity. Within the remit of this proposal we also plan to clone and overexpress the Class I aldolase of E. coli for comparative studies.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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