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Protein chemistry-based analysis of the structure/function of neurokinin (NK-2) G-protein coupled receptors
Reference
B02735
Principal Investigator / Supervisor
Professor John B C Findlay
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
315,701
Status
Completed
Type
Research Grant
Start date
01/10/1994
End date
30/04/1998
Duration
43 months
Abstract
Novel amino acids containing photoactivable moieties will be incorporated into peptide ligands and the NK-2 receptor in order to: (i) identify side chains/residues in the ligand and in the receptor apposition; (ii) investigate the orientation and conformation of the bound ligand; (iii) analyse helix-helix and receptor-G-protein contact regions. These studies will be carried out in addition to the analysis of the binding characteristics of mutant receptors.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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