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Free radical enzymes: structural, mechanistic and mutational studies of galactose oxidase
Reference
B02151
Principal Investigator / Supervisor
Professor Michael McPherson
Co-Investigators /
Co-Supervisors
Professor Peter Knowles
,
Professor Simon Phillips
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
166,572
Status
Completed
Type
Research Grant
Start date
01/09/1994
End date
01/09/1997
Duration
36 months
Abstract
(a)To characterise active site mutants of galactose oxidase to study catalysis, copper site and free radical reactivity through spectroscopic studies, including time-resolved methods, and X-ray crystallography. (b)To determine the X-ray structures of new wild-type and catalytic- intermediate forms of galactose oxidase. (c)To study the mechanism of formation of thebuilt-in cofactor involving the novel Tyr-Cys thioether bond.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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