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The role of small hydrophobic clusters in protein structures: de novo design and folding studies
Reference
B02071
Principal Investigator / Supervisor
Dr Philip Evans
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Biochemistry
Funding type
Research
Value (£)
124,869
Status
Completed
Type
Research Grant
Start date
15/11/1994
End date
15/11/1997
Duration
36 months
Abstract
1. To survey the occurrence of small exterior hydrophobic clusters in known protein structures, and to anatomise their structural roles, particularly with reference to widely occurring folding motifs. 2. To design hydrophobic clusters into peptides with the aim of stabilising their folding and enhancing its specificity. Later to extend this to small protein domains. 3. To engineer fluorophores into clusters of selected proteins, to allow kinetic studies.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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