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Interaction of HMG1 with DNA and chromatin: HMG-box and acidic domains
Reference
B02047
Principal Investigator / Supervisor
Professor Dame Jean Olwen Thomas
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Biochemistry
Funding type
Research
Value (£)
149,681
Status
Completed
Type
Research Grant
Start date
01/11/1995
End date
01/11/1998
Duration
36 months
Abstract
i) to determine the molecular basis of the interaction of the A and B-domain HMG boxes of HMG1 with DNA. ii) to determine the extent to which the two domains are able to function singly and the extent to which they cooperate within the intact protein. iii) to determine whether the HMG-box domains bind to chromatin, either singly or as pairs, in the absence of the highly acidic C-terminal tail.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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