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Analysis of the structure/function relationships in a novel family of polyol dehydrogenases

Reference	B01969
Principal Investigator / Supervisor	Professor David Rice
Co-Investigators / Co-Supervisors	Professor Michael Gore
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	179,043
Status	Completed
Type	Research Grant
Start date	01/10/1994
End date	01/05/1998
Duration	43 months

Abstract

1. To provide a molecular model for a novel superfamily of polyol dehydrogenases through the determination of the three dimensional structure of glycerol dehydrogenase. 2. To analyse the nucleotide, substrate and metal binding sites of glycerol dehydrogenase in order to understand the molecular basis of enzyme specificity chemistry. 3. To analyse the structure of the active site in order to produce proposals for the catalytic chemistry. 4. To use homology modelling to extend the analysis to other members of their enzyme family in order to understand differences in substrate and metal in specificity.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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