Award details

Assessment of the extent to which 3D structure predicts variation in chemical behaviour in an enzyme family

Reference	B01947
Principal Investigator / Supervisor	Professor K Brocklehurst
Co-Investigators / Co-Supervisors
Institution	Queen Mary University of London
Department	Sch of Biological and Chemical Sciences
Funding type	Research
Value (£)	151,556
Status	Completed
Type	Research Grant
Start date	01/02/1995
End date	15/04/1998
Duration	38 months

Abstract

(i) To contribute to understanding the ways in which binding interactions and remote ionisations determine catalytic site behaviour by stopped-flow kinetic analysis using systematic structural variation in a uniquely available series of time-dependent inhibitors and analogous substrates (ii) to assess the extent to which 3D-structures of the enzymes predict variation in chemical behaviour in an enzyme family using selected cysteine proteinases as a testbed (iii) to delineate the effects of specific binding interactions on the separate entropic and enthalpic contributions to reactivity.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

B04231 Assessment of the extent to which 3D structure predicts variation in chemical behaviour in an enzyme family

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