Award details

Generation of new natural and non-natural lantibiotics by genome mining and pathway engineering

Reference	APG20592
Principal Investigator / Supervisor	Professor Michael Gasson
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Food Safety Science Division
Funding type	Research
Value (£)	116,568
Status	Completed
Type	Research Grant
Start date	01/01/2004
End date	31/12/2005
Duration	24 months

Abstract

The objectives of this proposal are to combine genomic approaches to the discovery and characterisation of multiple lantibiotic gene clusters with genetic manipulation of the known gene cluster for cinnamycin to facilitate the generation of variant class B lantibiotics. The important cinnamycin class will be studied because of its potential therapeutic relevance and the presence of a number of natural variants which allows the control of specificity to be investigated. The therapeutic value of cinnamycin and artificial variants will be evaluated. (Joint with grant 20592)

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Applied Genomics (APG) [2000-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

APG20593 Generation of new natural and non-natural lantibiotics by genome mining and pathway engineering

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