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A High throughput protein folding chip
Reference
APG17769
Principal Investigator / Supervisor
Professor Anthony Cass
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
207,840
Status
Completed
Type
Research Grant
Start date
01/07/2002
End date
30/06/2006
Duration
48 months
Abstract
A novel chip based high throughput instrument had been developed by the industrial partner that will allow the measurement of protein thermal unfolding and refolding curves to be measured in a short period of time (a few minutes) in an exceptionally information rich fashion. This will be achieved by making label-free intrinsic imaging (LFII) measurement of the protein as it migrates through a thermal gradient in a micro-channel. The aim of this proposal is to work with the instrument developers to initially validate and then to extend the use of this instrument. Particular focus will be placed on using the LFII instrument to assess the functional significance of point mutations at the protein level and to measure ligand binding to proteins.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
LINK: Applied Genomics (APG) [2000-2004]
Funding Scheme
X – not Funded via a specific Funding Scheme
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