Award details

The role of eukaryotic internal ribosome entry in regulating expression of oncoproteins

Reference	AF13048
Principal Investigator / Supervisor	Professor Anne Willis
Co-Investigators / Co-Supervisors
Institution	University of Leicester
Department	Biochemistry
Funding type	Research
Value (£)	373,662
Status	Completed
Type	Fellowships
Start date	01/01/2000
End date	31/08/2004
Duration	56 months

Abstract

The objectives of this proposed research programme are: (1) to isolate and clone proteins which interact with the c-myc internal ribosome entry segment (IRES). (2) to identify protein partners of the c-myc IRES binding proteins. (3) to investigate expression and regulation of the IRES binding proteins. (4) to determine RNA/Protein interactions between c- myc IRS binding proteins and a range of IRESes. (5) to compare and contrast the c-myc IRES with IRESes in Myc family of genes. Targets to be met are: In 1-18 months: purify and clone c- myc IRES binding proteins. Over-express proteins in bacteria and purify to homogeneity. Establish collaborations with groups who are working on other IRES binding proteins. In 18- 36 months: Identify protein partners and investigate regulation of IRES binding proteins. In 36-48 months: determine RNA protein interactions. In 48-60 months: Studies on other Myc family IRESes.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Fellowship - Advanced Fellowship (AF) [1995-1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

AF13048/2 The role of eukaryotic internal ribosome entry in regulating expression of oncoproteins

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