Award details

Copper and prion protein function

Reference	AF13047
Principal Investigator / Supervisor	Professor David Brown
Co-Investigators / Co-Supervisors
Institution	University of Bath
Department	Biology and Biochemistry
Funding type	Research
Value (£)	342,086
Status	Completed
Type	Fellowships
Start date	03/01/2000
End date	03/01/2005
Duration	60 months

Abstract

The aim of the study is to investigate the function of prion protein (PrPc). More specifically the study will aim to identify the relevance of copper binding by PrPc to the metabolism of cells that express PrPc. The project will also seek to determine how loss of PrPc function might contribute to prion disease. Targets to be met are: In year 1-2: Determine relevance of PrPc expression to copper uptake, release and distribution. In year 2-3. Studies of recombinant PrPc to determine functional domains and any enzymatic activity. In year 2-4 Study with cells expressing PrPc and mutants give details of relevance to cell phenotype. In years 3-4 studies of copper starvation of PrP- knockout mice and will information on PrPc protection from changes in copper availability. End of Project: PrPc function defined; change in function of proteinase resistant PrP defined, functional domains defined; function changes with possible relevance to prion disease identified.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Fellowship - Advanced Fellowship (AF) [1995-1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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