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Neuronal integration underlying the computation of limb trajectory

ReferenceAF13046/2
Principal Investigator / Supervisor Dr Thomas Matheson
Co-Investigators /
Co-Supervisors
Institution University of Leicester
DepartmentBiology
Funding typeResearch
Value (£) 29,082
StatusCompleted
TypeFellowships
Start date 01/09/2004
End date 31/12/2004
Duration4 months

Abstract

I will elucidate basic principles of organisation that permit nervous systems to solve complex computational problems underlying limb targeting. The solutions to these spatio-temporal transformations are of central importance to all limbed animals, and of great interest to roboticists. I will use behavioural analyses and intracellular recording techniques in a newly developed insect preparation that is particularly favourable for the analysis of limb targeting. I will show how properties of individually identified neurones and the patterns of synaptic connections between them allow spatially patterned sensory information signalling target position to be integrated with limb postural information, to produce temporally patterned sequences of motor output that drive a limb along the correct trajectory to the target. In the first 18 months, I will determine how sensory information signalling stimulus position on a wing is represented in the central nervous system, and analyse the patterns of synaptic connections that transfer this information to local neuronal networks that can drive leg movements towards this position. In the next 30 months I will analyse how wing target information is integrated with leg postural information to define a leg trajectory through space. What frame of reference is used at each level of neuronal circuitry? In the final year I will analyse how these neuronal computations are modified to counteract changes in limb dynamics resulting from growth or damage.

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Fellowship - Advanced Fellowship (AF) [1995-1998]
Funding SchemeX – not Funded via a specific Funding Scheme
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