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Engineering novel protein photoreceptors for optoelectronics
Reference
AF11279
Principal Investigator / Supervisor
Dr Paul Barker
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
356,764
Status
Completed
Type
Fellowships
Start date
01/09/1998
End date
01/09/2003
Duration
60 months
Abstract
The objectives of the proposed research programme are to: 1. Couple photoisomerisation in a semisynthetic protein to the conformation of the protein and hence biological function. In particular, to work towards controlling electron transfer activity in a haem- containing optoelectronic system. 2. Identify protein structural elements of naturally occurring photosensor proteins which can be adapted for use in unnatural, technological environments. Targets to be reached during the programme are: 1. To contact a semisynthetic 4- helical bundle cytochrome incorporating an photoisomerisable group or groups (cinnamyl or azodiaryl derivatives) so that the protein conformation and haem binding is controlled by optical stimulation. 2. To examine the structure, folding and stability of PAS domains found in nature as components of a variety of sensor proteins, and to evaluate the possibility of using these in chimerae with DNA binding proteins.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Fellowship - Advanced Fellowship (AF) [1995-1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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