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Molecular genetic analysis and evolution of parasite resistance in the tropical freshwater snail Biomphalaria
Reference
AF09056
Principal Investigator / Supervisor
Dr Catherine Sue Jones
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
Inst of Biological and Environmental Sci
Funding type
Research
Value (£)
307,974
Status
Completed
Type
Fellowships
Start date
01/10/1997
End date
01/10/2002
Duration
60 months
Abstract
(1) Target regions of the B. glabrata genome involved in schistosome resistance for local linkage and interval mapping using bulk segregant analysis (BSA) of an already extant F2 population of B. glabrata. Markers will include Sequence Characterised Amplified Regions (SCARs) and Expressed Sequence Tags (ESTs), the latter recovered from haemocyte mRNA by differential display techniques. (2) Expand the number of markers by using F2 populations from other resistant and susceptible lines of B. glabrata to broaden the survey of the genotypic basis of resistance. (3) Isolate and characterise markers and expressed sequences closely linked to, or involved in, schistosome resistance. (4) Place the evolution of schistosome compatibility in a phylogenetic framework by analysis of orthologous genes involved in schistosome resistance, identified in (1), with mitochondrial genes and the Internal Transcribed Spacer (ITS) region of rRNA genes.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Fellowship - Advanced Fellowship (AF) [1995-1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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