Award details

The VWFA domains of integrins and complement - one domain one mechanism many functions?

ReferenceAF09053
Principal Investigator / Supervisor Dr Daniel Tuckwell
Co-Investigators /
Co-Supervisors
Institution The University of Manchester
DepartmentLife Sciences
Funding typeResearch
Value (£) 301,513
StatusCompleted
TypeFellowships
Start date 01/10/1997
End date 01/10/2002
Duration60 months

Abstract

Many proteins which are central to the multicellular lifestyle of organisms are made of module-like units which have been shuffled in the course of evolution. The VWFA domains are ligand-binding modules found in many animal proteins whose function is central to their parent molecules. Current data suggest that this domain family has a common mechanism of action, despite a diversity of roles. I aim to fully characterise the way in which the VWFA domains function, thereby greatly enhancing our understanding of the role of the many VWFA domain-containing proteins.

Summary

unavailable
Committee Closed Committee - Biomolecular Sciences (BMS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Fellowship - Advanced Fellowship (AF) [1995-1998]
Funding SchemeX – not Funded via a specific Funding Scheme
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