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Two-dimensional mapping of molecular interactions at the interfaces of next generation immunoassay systems

Reference	ABY08099
Principal Investigator / Supervisor	Professor Martyn Davies
Co-Investigators / Co-Supervisors	Professor Clive Roberts, Professor Saul Tendler, Professor Philip Williams
Institution	University of Nottingham
Department	Sch of Pharmacy
Funding type	Research
Value (£)	228,282
Status	Completed
Type	Research Grant
Start date	01/10/1997
End date	01/02/2001
Duration	40 months

Abstract

The focus of this proposal is the development of the technology for spatially mapping adhesion forces between receptors immobilised on a probe microscope tip and their ligands on immunoassay substrates. Data will be obtained at molecular resolution in aqueous environments. Localisation of such interactions will be combined with structural imaging. The correlation of this data to parameters describing molecular binding will be investigated. Results will be related to structural transformations during unbinding. The programme exploits the analytical expertise of the University of Nottingham and Johnson and Johnson Clinical Diagnostics and the instrumental know-how of the major international probe microscope manufacturer, Digital Instruments/LOT-Oriel.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Analytical Biotechnology (ABY) [1995-2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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