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Engineering hybrid pathways for cofactor-dependent transformations
Reference
ABC09854
Principal Investigator / Supervisor
Professor Neil Bruce
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Institute of Biotechnology
Funding type
Research
Value (£)
178,379
Status
Completed
Type
Research Grant
Start date
18/01/1999
End date
01/12/2002
Duration
46 months
Abstract
The project proposed by the Institute of Biotechnology and Macfarlan Smith Ltd aims to use recombinant DNA technology to address some of the problems encountered when using cofactor-dependent enzymes for biotransformation purposes. Major aspects of this proposal are to develop a new approach to cofactor recycling using recombinant soluble non-energy linked pyridine nucleotide transhydrogenases (STH) and to engineer extended recombinant pathways employing multiple cofactor-dependent enzymes. Work will also be directed towards the functional characterisation of STH and a novel morphinian alkaloid N- demethylase.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
LINK: Applied Biocatalysis (ABC) [1993-1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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