Award details

Biocatalytic synthesis of optically active sulphoxides

Reference	ABC09455
Principal Investigator / Supervisor	Professor H Dalton
Co-Investigators / Co-Supervisors
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	130,436
Status	Completed
Type	Research Grant
Start date	01/02/1998
End date	31/05/2001
Duration	40 months

Abstract

Sulphoxide reductases will be studied as biocatalysts for the kinetic resolution of racemic sulphoxides. The origin of the stereoselectivity and enantiocomplementarity, shown during preliminary deoxygenation studies will be examined in depth using both whole cell and purified sulphoxide reductases. A comparison of the sulphoxide reductase- and dioxygenase- catalysed methods will provide the optimal routes to enantiopure sulphoxides of interest in the pharmaceutical sector. A study of the potential of chiral sulphoxide bioproducts as chiral auxiliaries in the chemoenzymatic synthesis of less accessible types of sulphoxides, as dienophilic reagents for determination of enantiomeric excess, and as potential oxygen-atom transfer reagents, is planned. The ability of the reductase enzyme systems to catalyse other types of stereoselective deoxygenations will be assessed. (Joint with grant 81/ABC09451).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Applied Biocatalysis (ABC) [1993-1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

ABC09451 Biocatalytic synthesis of optically active sulphoxides and their application as chiral auxiliaries in asymmetric chemistry

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search