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Thermostable enzymes as catalysts for production of single enantiomeric compounds
Reference
ABC08239
Principal Investigator / Supervisor
Professor Jennifer Littlechild
Co-Investigators /
Co-Supervisors
Institution
University of Exeter
Department
Biosciences
Funding type
Research
Value (£)
122,773
Status
Completed
Type
Research Grant
Start date
01/02/1998
End date
01/06/2001
Duration
40 months
Abstract
The project aims: (1) To develop thermophilic archaeal enzymes as industrially useful biocatalysts. (2) To clone and overexpress specific amidohydrolases (gamma lactamases), amino acylase and esterases. (3) To develop procedures for biotransformation processes and to identify 'new chemistry' to study the effects of solvent and temperature on the enantiomeric selectivity of the enzymes. (4) To optimise the overexpression of selected enzymes and fermentation process. (5) To carry out purification and crystallisation of thermophilic catalysts. (6) To evaluate existing immobilisation techniques for enzymes of interest and the production of CLECS.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
LINK: Applied Biocatalysis (ABC) [1993-1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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