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Characterisation of essential protein/protein interactions required for DNA structure checkpoint function
Reference
9912402
Principal Investigator / Supervisor
Professor David Rice
Co-Investigators /
Co-Supervisors
Dr Clive Price
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
102,850
Status
Completed
Type
Research Grant
Start date
01/03/2000
End date
01/03/2002
Duration
24 months
Abstract
The checkpoint Rad proteins form a key intracellular signalling mechanism which acts to ensure the maintenance of genome stability, co-ordinating DNA structure alterations with the control of cell division. Here it is proposed to initiate a detailed functional investigation of complex formation between this group of proteins. This work will involve identification of specific complexes and kinetic analysis of complex formation using polyhistidine tagged, in vitro synthesised protein. In parallel we will initiate structural studies of the individual components utilising both X-ray crystallography and nuclear magnetic resonance spectroscopy.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1999 (ROPA1999) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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