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Construction of two-headed trypase inhibitors
Reference
9912372
Principal Investigator / Supervisor
Professor Robin Leatherbarrow
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Chemistry
Funding type
Research
Value (£)
91,224
Status
Completed
Type
Research Grant
Start date
01/02/2000
End date
01/02/2002
Duration
24 months
Abstract
Tryptase is a tetrameric proteinase implicated in asthma and inflammatory disorders. Recent structural data suggest that it should be possible to construct selective inhibitors by bridging between two or more of the adjacent active centres. This proposal is to produce and test a range of two-headed inhibitors, designed in light of the three dimensional structure, that act to bridge these sites.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1999 (ROPA1999) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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